Proinsulin and tyrosine hydroxilase/dopamine effects in cardiac development
Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid
www.cib.csic.es
Principal Investigator Flora de Pablo fdepablo@cib.csic.es Associate researcher Catalina Hernández Postdoctoral fellow Patricia Vázquez Lab technician Cayetana Murillo
Keywords
Proinsulin. Islet development. Insulin action. Cardiac complications.
Main lines of research
To explore whether higher than physiological embryonic expression of proinsulin has deleterious consequences during morphogenesis of the heart in a maternally independent model of development. The data show that inappropriately high proinsulin (which may occur in obese and type 2 diabetic pregnancies) leads to abnormal cardiac-specific gene expression and major heart malformations.
To characterize tyrosine hydroxilase (TH) expression pattern in mouse pancreas development, the analysis of TH function by studying pancreatic cell markers in TH-/- developing mice, and the effects of dopamine in embryonic pancreas explants. TH appears to be required to yield a normal number of beta cells in mice. Dopamine increases insulin expression in developing pancreas explants.
Publications
Glucagon-like peptide 1 (GLP-1) can reverse AMP-activated protein kinase (AMPK) and S6 kinase (P70S6K) activities induced by fluctuations in glucose levels in hypothalamic areas involved in feeding behaviour
Hurtado-Carneiro V, Sanz C, Roncero I, Vazquez P, Blazquez E, Alvarez E
Mol Neurobiol, 45, 348-361 (2012)
Article
Signaling and biological effects of glucagon-like peptide 1 on the differentiation of mesenchymal stem cells from human bone marrow
Sanz C, Vázquez P, Blázquez C, Barrio PA, Alvarez M del M, Blázquez E
Am J Physiol Endocrinol Metab, 298, E634-643 (2010)
Evolution of the insulin receptor family and receptor isoform expression in vertebrates
Hernández-Sánchez C, Mansilla A, de Pablo F, Zardoya R
Mol Biol Evol, 25, 1043-1053 (2008)
More info
2011 CIBERDEM Annual Report
2010 CIBERDEM Annual Report
2009 CIBERDEM Annual Report
2008 CIBERDEM Annual Report
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