CIBERDEM. Research. Brain glucose sensor, satiety control, insulin resistance and type 2 diabetes

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Brain glucose sensor, satiety control, insulin resistance and type 2 diabetes
Universidad Complutense de Madrid
www.ucm.es

Brain glucose sensor, satiety control, insulin
resistance and type 2 diabetes

Principal Investigator Enrique Blázquez eblazquez@med.ucm.es Associate researchers Elvira Álvarez García, María Ángeles Navas Hernández, Isabel Roncero Rincón, Juan Miguel Ruiz Albusac, María del Carmen Sanz Miguel, Esther Velázquez Sánchez PhD student Carmen García Herrero Lab manager Verónica Hurtado Carneiro

Keywords
Genetics type 2 diabetes. Incretins. Obesity. Insulin sensitivity and resistance. Insulin action. Carbohydrate metabolism. Biomarkers and imaging.

Main lines of research
Modifications of cerebral glucose metabolism in pathophysiological states related to feeding behaviour.
The effects of GLP-1 and GLP-2 on the expression and activity of hypothalamic metabolic sensors and characterization of the neuroprotective role of these peptides.
The effect of GLP-2 on the proliferation of cultured rat astrocytes.
Signalling and the biological effects of GLP-1 on mesenchymal stem cells of human bone marrow and mouse embryonic stem cells - its effect on cell differentiation.
Molecular diagnosis of monogenic diabetes (MODY) and the functional characterization of MODY mutations.

Publications
Glucagon-like peptide 1 (GLP-1) can reverse AMP-activated protein kinase (AMPK) and S6 kinase (P70S6K) activities induced by fluctuations in glucose levels in hypothalamic areas involved in feeding behaviour
Hurtado-Carneiro V, Sanz C, Roncero I, Vazquez P, Blazquez E, Alvarez E
Mol Neurobiol, 45, 348-361 (2012)
Article

Functional characterization of MODY2 mutations highlights the importance of the fine-tuning of glucokinase and its role in glucose sensing
García-Herrero CM, Rubio-Cabezas O, Azriel S, Gutierrez-Nogués A, Aragonés A, Vincent O, Campos-Barros A, Argente J, Navas MA
PLoS ONE, 7, e30518 (2012)
Article

Glucokinase (GCK) mutations and their characterization in MODY2 children of southern Italy
Capuano M, Garcia-Herrero CM, Tinto N, Carluccio C, Capobianco V, Coto I, Cola A, Iafusco D, Franzese A, Zagari A, Navas MA, Sacchetti L
PLoS ONE, 7, e38906 (2012)
Article

Glucagon-Like Peptide-2 (GLP-2) modulates the cGMP signalling pathway by regulating the expression of the soluble guanylyl cyclase receptor subunits in cultured rat astrocytes
Velázquez E, Blázquez E, Ruiz-Albusac JM
Mol Neurobiol, doi 10.1007/s12035-012-8298-1 (2012)
Article

Differential effects of HNF-1α mutations associated to familial young onset diabetes on target gene regulation
Galán M, García-Herrero CM, Azriel S, Gargallo M, Durán M, Gorgojo JJ, Andía VM, Navas MA
Mol Med, 17, 256-265 (2011)
Article

New gene targets for glucagon-like peptide-1 during embryonic development and in undifferentiated pluripotent cells
Sanz C, Blázquez E
Am J Physiol Endocrinol Metab, 301, E494-503 (2011)
Article

Signaling and biological effects of glucagon-like peptide 1 on the differentiation of mesenchymal stem cells from human bone marrow
Sanz C, Vázquez P, Blázquez C, Barrio PA, Alvarez M del M, Blázquez E
Am J Physiol Endocrinol Metab, 298, E634-643 (2010)

Glucokinase and glucokinase regulatory proteins are functionally coexpressed before birth in the rat brain
Roncero I, Sanz C, Álvarez E, Vázquez P, Barrio PA, Blázquez E
J Neuroendocrinol, 21, 973-981 (2009)