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Joan Guinovart, uno de los protagonistas del vídeo musical del IRB para atraer fondos a la investigación en diabetes, Alzheimer y cáncer.
Integrative analysis reveals novel pathways mediating the interaction between adipose tissue and pancreatic islets in obesity in rats.
The paper is focused on the integrative, multiplatform analysis of the interaction between the adipose tissue surrounding the pancreas and the pancreatic islets during the early phase of diet-induced obesity in rats.
During the development of obesity, the adaptation of the pancreatic beta cell mass is crucial to compensate for the rise in insulin demand and to maintain glucose homeostasis. The authors use a systems biology approach to integrate transcriptomic variations in pancreatic islets with changes in adipose tissue gene expression and protein and metabolite secretion in a rat model of diet-induced obesity and report that the liver/retinoid X receptors and inflammatory and immune response signalling pathways are key interaction nodes between these two tissues.
The cover picture shows an integrative network describing the crosstalk between the peripancreatic white adipose tissue and the pancreatic islets during the development of obesity in rats.
Horizon 2020The EU Framework Programme for Research and Innovation. ec.europa.eu/research/horizon2020